On the mode of action of Latrodectus spp. venom.
نویسنده
چکیده
منابع مشابه
Molecular Characterization, Electrophysiological and Contraceptive Effect of Chilean Latrodectus Venom Caracterización Molecular, Electrofisiológica y Efecto Anticonceptivo del Veneno de Latrodectus Chilena
Since the 1970s, There have been studies of the venom of Latrodectus sp. spiders, in particular the latrotoxin (LTX) of Latrodectus mactans. Many of the studies were aimed at understanding the action of the venom on the muscular system. Now accepted that LTX is able to generate a calcium-permeable membrane pore and modulate the release of synaptic vesicles that activate a receptor and induce ce...
متن کاملEffects of Gene Duplication, Positive Selection, and Shifts in Gene Expression on the Evolution of the Venom Gland Transcriptome in Widow Spiders
Gene duplication and positive selection can be important determinants of the evolution of venom, a protein-rich secretion used in prey capture and defense. In a typical model of venom evolution, gene duplicates switch to venom gland expression and change function under the action of positive selection, which together with further duplication produces large gene families encoding diverse toxins....
متن کاملEffect of the venom of the black widow spider, Latrodectus mactans tredecimguttatus, on evoked action potentials in the isolated nerve cord of Periplaneta americana.
INTRODUCTION NERI et al. (1965) found that Latrodectus tredecimguttatus venom at a minimal concentration of 400 hg of protein per ml upon application first enhanced and then suppressed the endogenous (spontaneous) activity recorded on one cereal nerve in the isolated nerve cord ofPeriplaneta americana. They also observed that the endogenous activity could be restored by immersing the cord in a ...
متن کاملSpecific Antivenom Ability in Neutralizing Hepatic and Renal Changes 24 Hours after Latrodectus dahli Envenomation
BACKGROUND Latrodectism, a syndrome caused by Latrodectus genus, is one of the clinical problems that occur predominantly in north east of Iran. Nowadays antivenom therapy has become the most useful treatment for animal bites; however there is still a controversy about route and time of antivenom administration in spider bite. The aim of the present study was to determine the efficacy of specif...
متن کاملRecent Advances in Research on Widow Spider Venoms and Toxins
Widow spiders have received much attention due to the frequently reported human and animal injures caused by them. Elucidation of the molecular composition and action mechanism of the venoms and toxins has vast implications in the treatment of latrodectism and in the neurobiology and pharmaceutical research. In recent years, the studies of the widow spider venoms and the venom toxins, particula...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Annali dell'Istituto superiore di sanita
دوره 7 1 شماره
صفحات -
تاریخ انتشار 1971